ABSTRACT
Background: Efficacy of these modalities as shown by various investigations are inconsistent and ambiguous. Thus, evidence based effective treatment option is warranted. Aim of the study was to compare the efficacy of oral ivermectin, topical permethrin and benzyl benzoate in the treatment of uncomplicated scabies.Methods: Patients with confirmed diagnosis of scabies were included in this study. One hundred and ninety-five subjects were included in this investigation as per inclusion and exclusion criteria laid down. Equal numbers of patients were randomly allocated to one of the three treatment groups. Efficacy of three groups [oral ivermectin (Group A), topical permethrin (Group B) and benzyl benzoate (Group C)] of drugs was compared in terms of improvement in clinical grading of disease (%) and improvement in clinical grading of pruritus (%) during follow up visits.Results: Those subjects receiving topical permethrin, at 1st follow up 56.9% showed cure rate which increased to 89.2% at 2nd follow up with respect to clinical improvement in pruritus. Maximum relief in severity of pruritus at the end of 6th week was reported by 58(89.2%) patients receiving group B treatment modality followed by 52 patients (80%) in arm A. Regarding efficacy of three treatment groups in terms of improvement in severity of lesion at the end of 6 weeks, maximum number of patients 57(87.7%), receiving group B treatment reported improvement which is better than other two treatment groups.Conclusions: maximum number of patients receiving topical Permethrin treatment reported improvement better than other Oral Ivermectin therapy and topical benzyl benzoate. Oral ivermectin may serve a good alternative for managing scabies under certain conditions like poor compliance to topical scabicides.
ABSTRACT
Tibial plateau fractures are intra-articular fractures caused by high-velocity trauma. They are usually associated with neurovascular injury, compartment syndrome, compounding of fractures, and crushing of soft tissues. The aim of our study is to investigate the benefits of using posterior approach and the surgical technique is beneficial for the union of fractures and prevention of postoperative complications in posterior fractures of the tibial plateau. Methods: This is a comparative prospective study on 50 adult patients was carried out in a tertiary level trauma center, after getting ethical committee clearance by the Institutional Review Board. All skeletally mature patients with closed tibial plateau fractures involving the posterior condyles confirmed on CT scan were included in the study. Open fractures, polytrauma, old or maluniting fractures, pathological fractures, and floating knee injuries or those associated with patella fractures were excluded from the study. Preoperative planning consisted of anteroposterior and lateral views in all cases and amount of displacement, depression and angulation were recorded. Computed tomography (CT) scan was kept as an option in cases where fracture pattern or amount of depression was unclear. Results: There were 22 male and 3 female in group A and in group B 21 Male and 4 female patients were mostly affected by traffic accidents. Most common mode of injury was road traffi c accidents; the second most common mode of injury was fall from height. Complications were not found to be significant in between the two groups. Perioperative parameters showed significant differences in both the groups; time for undertaking surgery posttrauma was significantly different. Conclusion: The fixation does not expedite the fracture healing, but rehabilitation and patient‑related scores are significantly better in our study. Surgical treatment with adequate physiotherapy can give good results in tibial plateau fractures.
ABSTRACT
Background: UTI is one of the commonest domiciliary and nosocomial bacterial infection, especially affecting the females. Nowadays antibiotic resistance among uropathogens is an emerging problem in treatment of UTI. Periodic assessment of antimicrobial susceptibility among the microorganisms will be fruitful in treating UTI. Aims: To study and assess the sensitivity/resistance pattern among E.coli and other uropathogens for nitrofurantoin, ofloxacin, Cotrimoxazole & 3rd generation cephalosporins. Methods: An observational, cross sectional study of 6 months duration from March 2016 to August 2016 was conducted on patients suffering from UTI in Department of Pharmacology and Department of Microbiology in FH Medical College & Hospital, Tundla, Uttar Pradesh. A total of 100 urine samples were analysed. Results: E.coli was the predominant (46%) uropathogen followed by Klebsiella (27%), Proteus (12%), Staphylococcus (7%), Pseudomonas (5%) and Enterococcus (3%). UTI was more common among females (61%) and illiterates (62%). Nitrofurantoin was the most sensitive (58%) antimicrobial followed by ofloxacin (35%). Conclusions: 3rd generation Cephalosporins showed higher percentage of resistance (78%).